Mito 2: "Se não é a SIRT1, o resveratrol não funciona para a longevidade."
Mesmo que a via da SIRT1 seja questionável, os efeitos benéficos do resveratrol não são. A ciência apenas descobriu um caminho diferente e mais fundamental: o resveratrol parece atuar em outras sirtuínas, especialmente as que residem nas nossas mitocôndrias.
A mesma pesquisa da PUC-RS que desafiou o mito da SIRT1 revelou uma nova pista fascinante. Tanto o resveratrol quanto a Restrição Calórica apresentaram um perfil de ação similar, diminuindo a expressão de dois outros genes da família: SIRT3 e SIRT4.
SIRT3 e SIRT4 são sirtuínas localizadas nas mitocôndrias, as “usinas de energia” de nossas células. Elas estão profundamente ligadas ao metabolismo, à resposta ao estresse e à saúde mitocondrial. Esta descoberta é crucial, pois desloca o foco de um único ‘gene da longevidade’ para um mecanismo mais fundamental: a saúde e eficiência das mitocôndrias, o verdadeiro motor do envelhecimento celular. Mito 3
F.A.Q.
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